Computer-aided detection of pulmonary nodules in low-dose CT

A computer-aided detection (CAD) system for the identification of pulmonary nodules in low-dose multi-detector helical CT images with 1.25 mm slice thickness is being developed in the framework of the INFN-supported MAGIC-5 Italian project. The basic modules of our lung-CAD system, a dot enhancement filter for nodule candidate selection and a voxel-based neural classifier for false-positive finding reduction, are described. Preliminary results obtained on the so-far collected database of lung CT scans are discussed.Comment: 3 pages, 4 figures; Proceedings of the CompIMAGE - International Symposium on Computational Modelling of Objects Represented in Images: Fundamentals, Methods and Applications, 20-21 Oct. 2006, Coimbra, Portuga

Evolution of the Mass-Metallicity relations in passive and star-forming galaxies from SPH-cosmological simulations

We present results from SPH-cosmological simulations, including self-consistent modelling of SN feedback and chemical evolution, of galaxies belonging to two clusters and twelve groups. We reproduce the mass-metallicity (ZM) relation of galaxies classified in two samples according to their star-forming activity, as parametrized by their sSFR, across a redshift range up to z=2. Its slope shows irrelevant evolution in the passive sample, being steeper in groups than in clusters. However, the sub-sample of high-mass passive galaxies only is characterized by a steep increase of the slope with redshift, from which it can be inferred that the bulk of the slope evolution of the ZM relation is driven by the more massive passive objects. (...ABRIDGED...) The ZM relation for the star-forming sample reveals an increasing scatter with redshift, indicating that it is still being built at early epochs. The star-forming galaxies make up a tight sequence in the SFR-M_* plane at high redshift, whose scatter increases with time alongside with the consolidation of the passive sequence. We also confirm the anti-correlation between sSFR and stellar mass, pointing at a key role of the former in determining the galaxy downsizing, as the most significant means of diagnostics of the star formation efficiency. Likewise, an anti-correlation between sSFR and metallicity can be established for the star-forming galaxies, while on the contrary more active galaxies in terms of simple SFR are also metal-richer. We discuss these results in terms of the mechanisms driving the evolution within the high- and low-mass regimes at different epochs: mergers, feedback-driven outflows and the intrinsic variation of the star formation efficiency.Comment: Emended list of author

A study on the multicolour evolution of Red Sequence galaxy populations: insights from hydrodynamical simulations and semi-analytical models

By means of our own cosmological-hydrodynamical simulation and semi-analytical model we studied galaxy population properties in clusters and groups, spanning over 10 different bands from UV to NIR, and their evolution since redshift z=2. We compare our results in terms of galaxy red/blue fractions and luminous-to-faint ratio (LFR) on the Red Sequence (RS) with recent observational data reaching beyond z=1.5. Different selection criteria were tested in order to retrieve galaxies belonging to the RS: either by their quiescence degree measured from their specific SFR ("Dead Sequence"), or by their position in a colour-colour plane which is also a function of sSFR. In both cases, the colour cut and the limiting magnitude threshold were let evolving with redshift, in order to follow the natural shift of the characteristic luminosity in the LF. We find that the Butcher-Oemler effect is wavelength-dependent, with the fraction of blue galaxies increasing steeper in optical colours than in NIR. Besides, only when applying a lower limit in terms of fixed absolute magnitude, a steep BO effect can be reproduced, while the blue fraction results less evolving when selecting samples by stellar mass or an evolving magnitude limit. We then find that also the RS-LFR behaviour, highly debated in the literature, is strongly dependent on the galaxy selection function: in particular its very mild evolution recovered when measured in terms of stellar mass, is in agreement with values reported for some of the highest redshift confirmed (proto)clusters. As to differences through environments, we find that normal groups and (to a lesser extent) cluster outskirts present the highest values of both star forming fraction and LFR at low z, while fossil groups and cluster cores the lowest: this separation among groups begins after z~0.5, while earlier all group star forming properties are undistinguishable.Comment: revised version, A&A accepted (11 pages, 6 figures

Anti-BVDV activity evaluation of naphthoimidazole derivatives compared with parental imidazoquinoline compounds.

Background: Pestivirus genus includes animal pathogens which are involved in economic impact for the livestock industry. Among others, Bovine Viral Diarrhoea Virus (BVDV) establish a persistent infection in cattle causing a long list of symptoms and a high mortality rate. In the last decades, we synthesised and reported a certain number of anti-BVDV compounds. Methods: In them, imidazoquinoline derivatives turned out as the most active. Their mechanism of actions has been deeply investigated, BVDV RNA-dependent RNA polymerase (RpRd) resulted as target and the way of binding was predicted in silico through three main H-bond interaction with the target. The prediction could be confirmed by target or ligand mutation. The first approach has already been performed and published confirming the in silico prediction. Results: Here, we present how the ligand chemical modification affects the anti-BVDV activity. The designed compounds were synthesised and tested against BVDV as in silico assay negative control. Conclusion: The antiviral results confirmed the predicted mechanism of action, as the newly synthesised compounds resulted not active in the in vitro BVDV infection inhibitio

Synthesis beyond the redox-active tetrathiafulvalene (TTF) molecule: From a topological control in TTF based macrocycles, towards functional chemical systems

Date du colloque&nbsp;: 05/2009</p

Phase Contrast Imaging Using a Single Picosecond X-ray Pulse of the Inverse Compton Source at the Bnl Accelerator Test Facility

Inverse Compton scattering (ICS) X-ray sources are of current interest due to their novel features that enable new methods in medical and biological imaging. As a compelling example of such a possibility, we present an experimental demonstration of single shot inline phase contrast imaging using the ICS source located at the BNL Accelerator Test Facility. The phase contrast effect is clearly observed in the images obtained. Further, its qualities are shown to be in agreement with the predictions of theoretical models through comparison of experimental and simulated images of a set of plastic wires of differing composition and size. We also display an example of application of the technique to single shot phase contrast imaging of a biological sample

An X-ray and optical study of the cluster A33

We report the first detailed X-ray and optical observations of the medium-distant cluster A33 obtained with the Beppo-SAX satellite and with the UH 2.2m and Keck II telescopes at Mauna Kea. The information deduced from X-ray and optical imaging and spectroscopic data allowed us to identify the X-ray source 1SAXJ0027.2-1930 as the X-ray counterpart of the A33 cluster. The faint, F_{2-10 keV} \approx 2.4 \times 10^{-13} \ergscm2, X-ray source 1SAXJ0027.2-1930, $\sim 2$ arcmin away from the optical position of the cluster as given in the Abell catalogue, is identified with the central region of A33. Based on six cluster galaxy redshifts, we determine the redshift of A33, $z=0.2409$; this is lower than the value derived by Leir and Van Den Bergh (1977). The source X-ray luminosity, L_{2-10 keV} = 7.7 \times 10^{43} \ergs, and intracluster gas temperature, $T = 2.9$ keV, make this cluster interesting for cosmological studies of the cluster $L_X-T$ relation at intermediate redshifts. Two other X-ray sources in the A33 field are identified. An AGN at z$=$0.2274, and an M-type star, whose emission are blended to form an extended X-ray emission $\sim 4$ arcmin north of the A33 cluster. A third possibly point-like X-ray source detected $\sim 3$ arcmin north-west of A33 lies close to a spiral galaxy at z$=$0.2863 and to an elliptical galaxy at the same redshift as the cluster.Comment: 9 pages, 6 Figures, Latex (using psfig,l-aa), to appear in Astronomy and Astrophysics S. (To get better quality copies of Figs.1-3 send an email to: [email protected]). A&AS, in pres

Automated detection of lung nodules in low-dose computed tomography

A computer-aided detection (CAD) system for the identification of pulmonary nodules in low-dose multi-detector computed-tomography (CT) images has been developed in the framework of the MAGIC-5 Italian project. One of the main goals of this project is to build a distributed database of lung CT scans in order to enable automated image analysis through a data and cpu GRID infrastructure. The basic modules of our lung-CAD system, consisting in a 3D dot-enhancement filter for nodule detection and a neural classifier for false-positive finding reduction, are described. The system was designed and tested for both internal and sub-pleural nodules. The database used in this study consists of 17 low-dose CT scans reconstructed with thin slice thickness (~300 slices/scan). The preliminary results are shown in terms of the FROC analysis reporting a good sensitivity (85% range) for both internal and sub-pleural nodules at an acceptable level of false positive findings (1-9 FP/scan); the sensitivity value remains very high (75% range) even at 1-6 FP/scanComment: 4 pages, 2 figures: Proceedings of the Computer Assisted Radiology and Surgery, 21th International Congress and Exhibition, Berlin, Volume 2, Supplement 1, June 2007, pp 357-35